USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

USC-OGP 2-DE database  Search by                Maps             Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal World-2DPAGE Repository Exclude local DBs has only effect if a remote interface is selected

Searching in 'USC-OGP 2-DE database' for entry matching: P18031 USC-OGP 2-DE database:  P18031 P18031 General information about the entry View entry in simple text format Entry name PTN1_HUMAN Primary accession number P18031 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Tyrosine-protein phosphatase non-receptor type 1; EC=3.1.3.48; AltName: Full=Protein-tyrosine phosphatase 1B; Short=PTP-1B;. Gene name Name=PTPN1 Synonyms=PTP1B Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_5-6 {PLATELET 5-6} Homo sapiens (Human)   map experimental info   PLATELET_5-6 MAP LOCATIONS: SPOT OGP-0710: pI=5.79; Mw=42372 Cross-references UniProtKB/Swiss-Prot P18031; PTN1_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name PTN1_HUMAN Primary accession number P18031 Secondary accession number(s) Q5TGD8 Q9BQV9 Q9NQQ4 Sequence was last modified on  November 1, 1990 (version 1) Annotations were last modified on  March 15, 2017 (version 212) Name and origin of the protein Description RecName: Full=Tyrosine-protein phosphatase non-receptor type 1; EC=3.1.3.48; AltName: Full=Protein-tyrosine phosphatase 1B; Short=PTP-1B; Gene name Name=PTPN1 Synonyms=PTP1B Encoded on Name=PTPN1; Synonyms=PTP1B Keywords 3D-structure; Acetylation; Complete proteome; Direct protein sequencing; Endoplasmic reticulum; Hydrolase; Membrane; Oxidation; Phosphoprotein; Polymorphism; Protein phosphatase; Reference proteome; S-nitrosylation. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL M31724; AAA60223.1; -; mRNA EMBL M33689; AAA60157.1; -; mRNA EMBL M33684; AAA60158.1; -; Genomic_DNA EMBL M33688; AAA60158.1; JOINED; Genomic_DNA EMBL M33687; AAA60158.1; JOINED; Genomic_DNA EMBL M33686; AAA60158.1; JOINED; Genomic_DNA EMBL M33685; AAA60158.1; JOINED; Genomic_DNA EMBL BT006752; AAP35398.1; -; mRNA EMBL AL133230; CAC00618.2; -; Genomic_DNA EMBL AL034429; CAC00618.2; JOINED; Genomic_DNA EMBL AL034429; CAI23215.1; -; Genomic_DNA EMBL AL133230; CAI23215.1; JOINED; Genomic_DNA EMBL BC015660; AAH15660.1; -; mRNA EMBL BC018164; AAH18164.1; -; mRNA CCDS CCDS13430.1; -; . PIR A35992; TPHUN1; . RefSeq NP_001265547.1; NM_001278618.1; . RefSeq NP_002818.1; NM_002827.3; . UniGene Hs.417549; -; . PDB 1A5Y; X-ray; 2.50 A; A=1-330 PDB 1AAX; X-ray; 1.90 A; A=1-321 PDB 1BZC; X-ray; 2.35 A; A=1-321 PDB 1BZH; X-ray; 2.10 A; A=1-298 PDB 1BZJ; X-ray; 2.25 A; A=2-298 PDB 1C83; X-ray; 1.80 A; A=1-298 PDB 1C84; X-ray; 2.35 A; A=1-298 PDB 1C85; X-ray; 2.72 A; A=1-298 PDB 1C86; X-ray; 2.30 A; A=1-298 PDB 1C87; X-ray; 2.10 A; A=1-298 PDB 1C88; X-ray; 1.80 A; A=1-298 PDB 1ECV; X-ray; 1.95 A; A=1-298 PDB 1EEN; X-ray; 1.90 A; A=1-321 PDB 1EEO; X-ray; 1.80 A; A=1-321 PDB 1G1F; X-ray; 2.00 A; A=1-298 PDB 1G1G; X-ray; 2.20 A; A=1-298 PDB 1G1H; X-ray; 2.40 A; A=1-298 PDB 1G7F; X-ray; 1.80 A; A=1-298 PDB 1G7G; X-ray; 2.20 A; A=1-298 PDB 1GFY; X-ray; 2.13 A; A=1-298 PDB 1I57; X-ray; 2.10 A; A=1-298 PDB 1JF7; X-ray; 2.20 A; A/B=1-298 PDB 1KAK; X-ray; 2.50 A; A=1-298 PDB 1KAV; X-ray; 2.35 A; A=1-298 PDB 1L8G; X-ray; 2.50 A; A=1-321 PDB 1LQF; X-ray; 2.50 A; A/B/C/D=1-283 PDB 1NL9; X-ray; 2.40 A; A=1-321 PDB 1NNY; X-ray; 2.40 A; A=1-321 PDB 1NO6; X-ray; 2.40 A; A=1-321 PDB 1NWE; X-ray; 3.10 A; A=1-298 PDB 1NWL; X-ray; 2.40 A; A=1-298 PDB 1NZ7; X-ray; 2.40 A; A=1-321 PDB 1OEM; X-ray; 1.80 A; X=1-321 PDB 1OEO; X-ray; 2.15 A; X=1-321 PDB 1OES; X-ray; 2.20 A; A=1-321 PDB 1OET; X-ray; 2.30 A; A=1-321 PDB 1OEU; X-ray; 2.50 A; A=1-321 PDB 1OEV; X-ray; 2.20 A; A=1-321 PDB 1ONY; X-ray; 2.15 A; A=1-321 PDB 1ONZ; X-ray; 2.40 A; A=1-321 PDB 1PA1; X-ray; 1.60 A; A=1-298 PDB 1PH0; X-ray; 2.20 A; A=1-321 PDB 1PTT; X-ray; 2.90 A; A=1-321 PDB 1PTU; X-ray; 2.60 A; A=1-321 PDB 1PTV; X-ray; 2.30 A; A=1-321 PDB 1PTY; X-ray; 1.85 A; A=1-321 PDB 1PXH; X-ray; 2.15 A; A=1-321 PDB 1PYN; X-ray; 2.20 A; A=1-321 PDB 1Q1M; X-ray; 2.60 A; A=1-321 PDB 1Q6J; X-ray; 2.20 A; A=1-298 PDB 1Q6M; X-ray; 2.20 A; A=1-298 PDB 1Q6N; X-ray; 2.10 A; A/B=1-298 PDB 1Q6P; X-ray; 2.30 A; A/B=1-298 PDB 1Q6S; X-ray; 2.20 A; A/B=1-298 PDB 1Q6T; X-ray; 2.30 A; A/B=1-298 PDB 1QXK; X-ray; 2.30 A; A=1-321 PDB 1SUG; X-ray; 1.95 A; A=1-321 PDB 1T48; X-ray; 2.20 A; A=1-298 PDB 1T49; X-ray; 1.90 A; A=1-298 PDB 1T4J; X-ray; 2.70 A; A=1-298 PDB 1WAX; X-ray; 2.20 A; A=1-321 PDB 1XBO; X-ray; 2.50 A; A=1-321 PDB 2AZR; X-ray; 2.00 A; A=1-299 PDB 2B07; X-ray; 2.10 A; A=1-299 PDB 2B4S; X-ray; 2.30 A; A/C=1-298 PDB 2BGD; X-ray; 2.40 A; A=1-321 PDB 2BGE; X-ray; 1.80 A; A=1-321 PDB 2CM2; X-ray; 1.50 A; A=2-298 PDB 2CM3; X-ray; 2.10 A; A/B=1-298 PDB 2CM7; X-ray; 2.10 A; A=1-321 PDB 2CM8; X-ray; 2.10 A; A=1-321 PDB 2CMA; X-ray; 2.30 A; A=1-321 PDB 2CMB; X-ray; 1.70 A; A=1-298 PDB 2CMC; X-ray; 2.20 A; A=1-298 PDB 2CNE; X-ray; 1.80 A; A=1-298 PDB 2CNF; X-ray; 2.20 A; A=1-321 PDB 2CNG; X-ray; 1.90 A; A=1-321 PDB 2CNH; X-ray; 1.80 A; A=1-321 PDB 2CNI; X-ray; 2.00 A; A=1-321 PDB 2F6F; X-ray; 2.00 A; A=1-298 PDB 2F6T; X-ray; 1.70 A; A=1-298 PDB 2F6V; X-ray; 1.70 A; A=1-298 PDB 2F6W; X-ray; 2.20 A; A=1-298 PDB 2F6Y; X-ray; 2.15 A; A=1-298 PDB 2F6Z; X-ray; 1.70 A; A=1-298 PDB 2F70; X-ray; 2.12 A; A=1-298 PDB 2F71; X-ray; 1.55 A; A=1-298 PDB 2FJM; X-ray; 2.10 A; A/B=1-298 PDB 2FJN; X-ray; 2.20 A; A/B=1-298 PDB 2H4G; X-ray; 2.50 A; A=1-299 PDB 2H4K; X-ray; 2.30 A; A=1-299 PDB 2HB1; X-ray; 2.00 A; A=1-299 PDB 2HNP; X-ray; 2.85 A; A=1-321 PDB 2HNQ; X-ray; 2.85 A; A=1-321 PDB 2NT7; X-ray; 2.10 A; A=1-299 PDB 2NTA; X-ray; 2.10 A; A=1-299 PDB 2QBP; X-ray; 2.50 A; A=1-299 PDB 2QBQ; X-ray; 2.10 A; A=1-299 PDB 2QBR; X-ray; 2.30 A; A=1-299 PDB 2QBS; X-ray; 2.10 A; A=1-299 PDB 2VEU; X-ray; 2.40 A; A=1-321 PDB 2VEV; X-ray; 1.80 A; A=1-321 PDB 2VEW; X-ray; 2.00 A; A=1-321 PDB 2VEX; X-ray; 2.20 A; A=1-321 PDB 2VEY; X-ray; 2.20 A; A=1-321 PDB 2ZMM; X-ray; 2.10 A; A=1-299 PDB 2ZN7; X-ray; 2.10 A; A=1-299 PDB 3A5J; X-ray; 1.70 A; A=2-321 PDB 3A5K; X-ray; 1.85 A; A=2-298 PDB 3CWE; X-ray; 1.60 A; A=1-283 PDB 3D9C; X-ray; 2.30 A; A=1-321 PDB 3EAX; X-ray; 1.90 A; A=1-321 PDB 3EB1; X-ray; 2.40 A; A=1-321 PDB 3EU0; X-ray; 2.70 A; A=1-282 PDB 3I7Z; X-ray; 2.30 A; A=1-321 PDB 3I80; X-ray; 2.25 A; A=1-321 PDB 3QKP; X-ray; 2.05 A; A=1-321 PDB 3QKQ; X-ray; 2.20 A; A=1-321 PDB 3SME; X-ray; 1.70 A; A=1-298 PDB 3ZMP; X-ray; 2.62 A; A/B=1-321 PDB 3ZMQ; X-ray; 3.30 A; A=1-321 PDB 3ZV2; X-ray; 2.80 A; A=1-320 PDB 4BJO; X-ray; 2.06 A; A/B=2-321 PDB 4I8N; X-ray; 2.50 A; A=1-320 PDB 4QAH; X-ray; 2.40 A; A=1-299 PDB 4QAP; X-ray; 1.90 A; A=1-299 PDB 4QBE; X-ray; 2.29 A; A=1-298 PDB 4QBW; X-ray; 1.91 A; A=1-299 PDB 4Y14; X-ray; 1.90 A; A/B=2-301 PDB 4ZRT; X-ray; 1.74 A; A=1-298 PDBsum 1A5Y; -; . PDBsum 1AAX; -; . PDBsum 1BZC; -; . PDBsum 1BZH; -; . PDBsum 1BZJ; -; . PDBsum 1C83; -; . PDBsum 1C84; -; . PDBsum 1C85; -; . PDBsum 1C86; -; . PDBsum 1C87; -; . PDBsum 1C88; -; . PDBsum 1ECV; -; . PDBsum 1EEN; -; . PDBsum 1EEO; -; . PDBsum 1G1F; -; . PDBsum 1G1G; -; . PDBsum 1G1H; -; . PDBsum 1G7F; -; . PDBsum 1G7G; -; . PDBsum 1GFY; -; . PDBsum 1I57; -; . PDBsum 1JF7; -; . PDBsum 1KAK; -; . PDBsum 1KAV; -; . PDBsum 1L8G; -; . PDBsum 1LQF; -; . PDBsum 1NL9; -; . PDBsum 1NNY; -; . PDBsum 1NO6; -; . PDBsum 1NWE; -; . PDBsum 1NWL; -; . PDBsum 1NZ7; -; . PDBsum 1OEM; -; . PDBsum 1OEO; -; . PDBsum 1OES; -; . PDBsum 1OET; -; . PDBsum 1OEU; -; . PDBsum 1OEV; -; . PDBsum 1ONY; -; . PDBsum 1ONZ; -; . PDBsum 1PA1; -; . PDBsum 1PH0; -; . PDBsum 1PTT; -; . PDBsum 1PTU; -; . PDBsum 1PTV; -; . PDBsum 1PTY; -; . PDBsum 1PXH; -; . PDBsum 1PYN; -; . PDBsum 1Q1M; -; . PDBsum 1Q6J; -; . PDBsum 1Q6M; -; . PDBsum 1Q6N; -; . PDBsum 1Q6P; -; . PDBsum 1Q6S; -; . PDBsum 1Q6T; -; . PDBsum 1QXK; -; . PDBsum 1SUG; -; . PDBsum 1T48; -; . PDBsum 1T49; -; . PDBsum 1T4J; -; . PDBsum 1WAX; -; . PDBsum 1XBO; -; . PDBsum 2AZR; -; . PDBsum 2B07; -; . PDBsum 2B4S; -; . PDBsum 2BGD; -; . PDBsum 2BGE; -; . PDBsum 2CM2; -; . PDBsum 2CM3; -; . PDBsum 2CM7; -; . PDBsum 2CM8; -; . PDBsum 2CMA; -; . PDBsum 2CMB; -; . PDBsum 2CMC; -; . PDBsum 2CNE; -; . PDBsum 2CNF; -; . PDBsum 2CNG; -; . PDBsum 2CNH; -; . PDBsum 2CNI; -; . PDBsum 2F6F; -; . PDBsum 2F6T; -; . PDBsum 2F6V; -; . PDBsum 2F6W; -; . PDBsum 2F6Y; -; . PDBsum 2F6Z; -; . PDBsum 2F70; -; . PDBsum 2F71; -; . PDBsum 2FJM; -; . PDBsum 2FJN; -; . PDBsum 2H4G; -; . PDBsum 2H4K; -; . PDBsum 2HB1; -; . PDBsum 2HNP; -; . PDBsum 2HNQ; -; . PDBsum 2NT7; -; . PDBsum 2NTA; -; . PDBsum 2QBP; -; . PDBsum 2QBQ; -; . PDBsum 2QBR; -; . PDBsum 2QBS; -; . PDBsum 2VEU; -; . PDBsum 2VEV; -; . PDBsum 2VEW; -; . PDBsum 2VEX; -; . PDBsum 2VEY; -; . PDBsum 2ZMM; -; . PDBsum 2ZN7; -; . PDBsum 3A5J; -; . PDBsum 3A5K; -; . PDBsum 3CWE; -; . PDBsum 3D9C; -; . PDBsum 3EAX; -; . PDBsum 3EB1; -; . PDBsum 3EU0; -; . PDBsum 3I7Z; -; . PDBsum 3I80; -; . PDBsum 3QKP; -; . PDBsum 3QKQ; -; . PDBsum 3SME; -; . PDBsum 3ZMP; -; . PDBsum 3ZMQ; -; . PDBsum 3ZV2; -; . PDBsum 4BJO; -; . PDBsum 4I8N; -; . PDBsum 4QAH; -; . PDBsum 4QAP; -; . PDBsum 4QBE; -; . PDBsum 4QBW; -; . PDBsum 4Y14; -; . PDBsum 4ZRT; -; . ProteinModelPortal P18031; -; . SMR P18031; -; . BioGrid 111736; 102; . DIP DIP-38014N; -; . IntAct P18031; 128; . MINT MINT-441655; -; . STRING 9606.ENSP00000360683; -; . BindingDB P18031; -; . ChEMBL CHEMBL335; -; . DrugBank DB08783; (4-{(2S)-2-[(tert-butoxycarbonyl)amino]-3-methoxy-3-oxopropyl}phenyl)methaneseleninic acid; . DrugBank DB04800; 1-METHYL-3-PHENYL-1H-PYRAZOL-5-YLSULFAMIC ACID; . DrugBank DB04525; 2-(Carboxymethoxy)-5-[(2s)-2-({(2s)-2-[(3-Carboxypropanoyl)Amino] -3-Phenylpropanoyl}Amino)-3-Oxo-3-(Pentylamino)Propyl]Benzoic Acid; . DrugBank DB02622; 2-(Oxalyl-Amino)-Benzoic Acid; . DrugBank DB07295; 2-[(7-HYDROXY-NAPHTHALEN-1-YL)-OXALYL-AMINO]-BENZOIC ACID; . DrugBank DB02436; 2-{4-[(2s)-2-[({[(1s)-1-Carboxy-2-Phenylethyl]Amino}Carbonyl)Amino]-3-Oxo-3-(Pentylamino)Propyl]Phenoxy}Malonic Acid; . DrugBank DB01734; 3-(Oxalyl-Amino)-Naphthalene-2-Carboxylic Acid; . DrugBank DB03483; 4-Benzoylamino-4-{1-{1-Carbamoyl-2-[4-(Difluoro-Phosphono-Methyl)-Phenyl]-Ethylcarbamoyl}-2-[4-(Difluoro-Phosphono-Methyl)-Phenyl]-Ethylcarbamoyl}-Butyric Acid; . DrugBank DB07197; 4-BROMO-3-(CARBOXYMETHOXY)-5-(4-HYDROXYPHENYL)THIOPHENE-2-CARBOXYLIC ACID; . DrugBank DB06829; 4-BROMO-3-(CARBOXYMETHOXY)-5-[3-(CYCLOHEXYLAMINO)PHENYL]THIOPHENE-2-CARBOXYLIC ACID; . DrugBank DB07130; 4-BROMO-3-(CARBOXYMETHOXY)-5-PHENYLTHIOPHENE-2-CARBOXYLIC ACID; . DrugBank DB03714; 4-Carbamoyl-4-{[6-(Difluoro-Phosphono-Methyl)-Naphthalene-2-Carbonyl]-Amino}-Butyric Acid; . DrugBank DB07480; 4-PHOSPHONOOXY-PHENYL-METHYL-[4-PHOSPHONOOXY]BENZEN; . DrugBank DB08001; 5-(3-{3-[3-HYDROXY-2-(METHOXYCARBONYL)PHENOXY]PROPENYL}PHENYL)-4-(HYDROXYMETHYL)ISOXAZOLE-3-CARBOXYLIC ACID; . DrugBank DB07289; 5-[3-(BENZYLAMINO)PHENYL]-4-BROMO-3-(CARBOXYMETHOXY)THIOPHENE-2-CARBOXYLIC ACID; . DrugBank DB08397; 6-(DIFLUORO-PHOSPHONO-METHYL)-NAPHTHALENE-2-CARBOXYLIC ACID; . DrugBank DB04001; 6-(Oxalyl-Amino)-1h-Indole-5-Carboxylic Acid; . DrugBank DB04204; [(4-{4-[4-(Difluoro-Phosphono-Methyl)-Phenyl]-Butyl}-Phenyl)-Difluoro-Methyl]-Phosphonic Acid; . DrugBank DB02615; Compound 19; . DrugBank DB02014; Compound 9; . DrugBank DB03661; Cysteinesulfonic Acid; . DrugBank DB05506; ISIS 113715; . DrugBank DB08003; ISOTHIAZOLIDINONE ANALOG; . DrugBank DB04088; N-(Allyloxycarbonyl)-4-[N-(Carboxy-Formyl)-2-(Benzoic Acid)-Amino]-L-Phenylalaninyl-Amino-Butyloxy-(6-Hydroxy-Benzoic Acid Methyl Ester); . DrugBank DB02784; N-[4-(2-{2-[3-(2-Bromo-Acetylamino)-Propionylamino]-3-Hydroxy-Propionylamino}-Ethyl)-Phenyl]-Oxalamic Acid; . DrugBank DB07651; N-ACETYL-L-PHENYLALANYL-4-[DIFLUORO(PHOSPHONO)METHYL]-L-PHENYLALANINAMIDE; . DrugBank DB03557; N-{1-[5-(1-Carbamoyl-2-Mercapto-Ethylcarbamoyl)-Pentylcarbamoyl]-2-[4-(Difluoro-Phosphono-Methyl)-Phenyl]-Ethyl}-3-{2-[4-(Difluoro-Phosphono-Methyl)-Phenyl]-Acetylamino}-Succinamic Acid; . DrugBank DB02662; Novo Nordisk a/S Compound; . DrugBank DB08371; PARA-(BENZOYL)-PHENYLALANINE; . DrugBank DB02977; PNU177836; . DrugBank DB02620; Sp7343-Sp7964; . DrugBank DB01133; Tiludronate; . DrugBank DB03154; {[7-(Difluoro-Phosphono-Methyl)-Naphthalen-2-Yl]-Difluoro-Methyl}-Phosphonic Acid; . DEPOD P18031; -; . iPTMnet P18031; -; . PhosphoSitePlus P18031; -; . SwissPalm P18031; -; . DMDM 131467; -; . OGP P18031; -; . EPD P18031; -; . MaxQB P18031; -; . PaxDb P18031; -; . PeptideAtlas P18031; -; . PRIDE P18031; -; . DNASU 5770; -; . Ensembl ENST00000371621; ENSP00000360683; ENSG00000196396; . GeneID 5770; -; . KEGG hsa:5770; -; . UCSC uc002xvl.5; human; . CTD 5770; -; . DisGeNET 5770; -; . GeneCards PTPN1; -; . H-InvDB HIX0027718; -; . HGNC HGNC:9642; PTPN1; . HPA CAB009329; -; . HPA CAB015217; -; . HPA HPA012542; -; . MalaCards PTPN1; -; . MIM 176885; gene; . neXtProt NX_P18031; -; . OpenTargets ENSG00000196396; -; . PharmGKB PA33985; -; . eggNOG KOG0789; Eukaryota; . eggNOG COG5599; LUCA; . GeneTree ENSGT00870000136380; -; . HOGENOM HOG000273908; -; . HOVERGEN HBG008321; -; . InParanoid P18031; -; . KO K05696; -; . OMA DGPIKEE; -; . OrthoDB EOG091G082B; -; . PhylomeDB P18031; -; . TreeFam TF315897; -; . BRENDA 3.1.3.48; 2681; . Reactome R-HSA-354192; Integrin alphaIIb beta3 signaling; . Reactome R-HSA-6807004; Negative regulation of MET activity; . Reactome R-HSA-877312; Regulation of IFNG signaling; . Reactome R-HSA-8849472; PTK6 Down-Regulation; . Reactome R-HSA-912694; Regulation of IFNA signaling; . Reactome R-HSA-982772; Growth hormone receptor signaling; . SABIO-RK P18031; -; . SignaLink P18031; -; . SIGNOR P18031; -; . ChiTaRS PTPN1; human; . EvolutionaryTrace P18031; -; . GeneWiki PTPN1; -; . GenomeRNAi 5770; -; . PMAP-CutDB P18031; -; . PRO PR:P18031; -; . Proteomes UP000005640; Chromosome 20; . Bgee ENSG00000196396; -; . CleanEx HS_PTPN1; -; . ExpressionAtlas P18031; baseline and differential; . Genevisible P18031; HS; . GO GO:0098554; C:cytoplasmic side of endoplasmic reticulum membrane; IDA:ParkinsonsUK-UCL; . GO GO:0005829; C:cytosol; TAS:Reactome; . GO GO:0005769; C:early endosome; IDA:UniProtKB; . GO GO:0005783; C:endoplasmic reticulum; IDA:HPA; . GO GO:0097443; C:sorting endosome; ISS:BHF-UCL; . GO GO:0045296; F:cadherin binding; IDA:BHF-UCL; . GO GO:0019899; F:enzyme binding; IPI:UniProtKB; . GO GO:0046875; F:ephrin receptor binding; IPI:UniProtKB; . GO GO:0019901; F:protein kinase binding; IPI:UniProtKB; . GO GO:0004725; F:protein tyrosine phosphatase activity; IDA:UniProtKB; . GO GO:0030971; F:receptor tyrosine kinase binding; IPI:UniProtKB; . GO GO:0003723; F:RNA binding; IDA:UniProtKB; . GO GO:0008270; F:zinc ion binding; IDA:UniProtKB; . GO GO:0031532; P:actin cytoskeleton reorganization; IMP:UniProtKB; . GO GO:0007257; P:activation of JUN kinase activity; IEA:Ensembl; . GO GO:0006987; P:activation of signaling protein activity involved in unfolded protein response; TAS:ParkinsonsUK-UCL; . GO GO:0030968; P:endoplasmic reticulum unfolded protein response; IDA:UniProtKB; . GO GO:0008286; P:insulin receptor signaling pathway; IEA:Ensembl; . GO GO:0036498; P:IRE1-mediated unfolded protein response; IEA:Ensembl; . GO GO:0060397; P:JAK-STAT cascade involved in growth hormone signaling pathway; TAS:Reactome; . GO GO:1902236; P:negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; IEA:Ensembl; . GO GO:0070373; P:negative regulation of ERK1 and ERK2 cascade; ISS:BHF-UCL; . GO GO:0046627; P:negative regulation of insulin receptor signaling pathway; NAS:BHF-UCL; . GO GO:0043407; P:negative regulation of MAP kinase activity; IMP:CACAO; . GO GO:1903898; P:negative regulation of PERK-mediated unfolded protein response; IDA:ParkinsonsUK-UCL; . GO GO:0009968; P:negative regulation of signal transduction; TAS:Reactome; . GO GO:0030948; P:negative regulation of vascular endothelial growth factor receptor signaling pathway; ISS:BHF-UCL; . GO GO:0035335; P:peptidyl-tyrosine dephosphorylation; IDA:UniProtKB; . GO GO:1990264; P:peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity; ISS:BHF-UCL; . GO GO:0035791; P:platelet-derived growth factor receptor-beta signaling pathway; IMP:UniProtKB; . GO GO:1903896; P:positive regulation of IRE1-mediated unfolded protein response; TAS:ParkinsonsUK-UCL; . GO GO:0061098; P:positive regulation of protein tyrosine kinase activity; IDA:ParkinsonsUK-UCL; . GO GO:2000646; P:positive regulation of receptor catabolic process; IMP:CACAO; . GO GO:0006470; P:protein dephosphorylation; IMP:CACAO; . GO GO:0030100; P:regulation of endocytosis; IDA:UniProtKB; . GO GO:1902202; P:regulation of hepatocyte growth factor receptor signaling pathway; IMP:UniProtKB; . GO GO:0033157; P:regulation of intracellular protein transport; IMP:CACAO; . GO GO:0009966; P:regulation of signal transduction; IMP:UniProtKB; . GO GO:0060338; P:regulation of type I interferon-mediated signaling pathway; TAS:Reactome; . Gene3D 3.90.190.10; -; 1; . InterPro IPR029021; Prot-tyrosine_phosphatase-like; . InterPro IPR000242; PTPase_domain; . InterPro IPR012265; Ptpn1/Ptpn2; . InterPro IPR016130; Tyr_Pase_AS; . InterPro IPR003595; Tyr_Pase_cat; . InterPro IPR000387; TYR_PHOSPHATASE_dom; . Pfam PF00102; Y_phosphatase; 1; . PIRSF PIRSF000926; Tyr-Ptase_nr1; 1; . PRINTS PR00700; PRTYPHPHTASE; . SMART SM00194; PTPc; 1; . SMART SM00404; PTPc_motif; 1; . SUPFAM SSF52799; SSF52799; 1; . PROSITE PS00383; TYR_PHOSPHATASE_1; 1; . PROSITE PS50056; TYR_PHOSPHATASE_2; 1; . PROSITE PS50055; TYR_PHOSPHATASE_PTP; 1; .

Gateways to other related servers

• The World-2DPAGE Constellation - Entry point to the world-wide 2-DPAGE resources.
• World-2DPAGE Repository - A public repository for gel-based proteomics data linked to protein identification published in the literature.
• World-2DPAGE Portal - A dynamic portal to query simultaneously world-wide gel-based proteomics databases.
• SWISS-2DPAGE - The Geneva Two-dimensional polyacrylamide gel electrophoresis database.
• ExPASy - The resources web server of the Swiss Institute of Bioinformatics

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